Publications

The Lancet Publications on the effect of candesartan on prevention in Type 1 diabetes (DIRECT-Prevent 1) and progression in Type 1 and Type 2 diabetes (DIRECT-Protect 1 and DIRECT-Protect 2) are now available.

Effect of candesartan on microalbuminuria and albumin excretion rate in diabetes: three randomized trials
Bilous R, Chaturvedi N, Sjolie AK, Fuller J, Klein R, Orchard T, Porta M and Parving HH
Annals of Internal Medicine 2009; 151: 11-20
Click here to download
(PC platform only, chose save option then double click downloaded file to validate and view)

The effect of the angiotensin receptor blocker candesartan on regression of retinopathy in type 2 diabetes
Sjolie AK, Klein R, Chaturvedi N, Porta M, Fuller J, Orchard T, Bilous R and Parving HH
Investigative Ophthalmology and Visual Science 2009; 50: E-Abstract 1679
Click here to view the abstract (opens new window)
Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials
Chaturvedi N, Porta M, Klein R, Orchard T, Fuller J, Parving HH, Bilous R and Sjolie AK
The Lancet 2008; 372: 1394-1402
Click here to download (opens new window)
Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial
Sjolie AK, Klein R, Porta M, Orchard T, Fuller J, Parving HH, Bilous R and Chaturvedi N
Lancet 2008; 372: 1385-93
Click here to download (opens new window)
The DIabetic REtinopathy Candesartan Trials (DIRECT) Programme: baseline characteristics
The DIRECT Programme Study Group
Journal of the Renin-Angiotensin-Aldosterone System 2005; 6: 25–32
Click here to download
The DIabetic REtinopathy Candesartan Trials (DIRECT) Programme, rationale and study design
The DIRECT Programme Study Group and Chaturvedi N
Journal of the Renin-Angiotensin-Aldosterone System 2002; 3: 255–261
Click here to download